Expressions of tight junction proteins Occludin and Claudin-1 are under the circadian control in the mouse large intestine: implications in intestinal permeability and susceptibility to colitis.

BACKGROUND & AIMS: The circadian clock drives daily rhythms in behavior and physiology.A recent study suggests that intestinal permeability is also under control of the circadian clock.However, the precise mechanisms remain largely unknown.Because intestinal permeability depends on tight junction (TJ) that regulates the epithelial paracellular path

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Posterior reversible encephalopathy syndrome in spotted fever group of rickettsial infection with brugada syndrome

Rickettsioses are one of the common causes of undifferentiated febrile illness.Patients present commonly with fever, rash, and eschar.Posterior Reversible Encephalopathy Syndrome (PRES) also known as reversible STRENGTHENING FOOD SECURITY THROUGH THE USE OF YARDS DURING THE COVID 19 PANDEMIC posterior encephalopathy syndrome is a rare condition, in

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Clinically significant genomic alterations in the Chinese and Western patients with intrahepatic cholangiocarcinoma

Abstract Background The goal of this study is to disclose the clinically significant genomic alterations in the Chinese and Western patients with intrahepatic cholangiocarcinoma.Methods A total of 86 Chinese patients were enrolled in this study.A panel of 579 pan-cancer genes was sequenced for the qualified samples from these patients.Driver genes,

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